AB0606 IMPACT OF ABDOMINAL AORTIC CALCIFICATION AND SERUM CREATININE-TO-CYSTATIN C RATIO TO BONE FRAGILITY FRACTURE

Background: Relationship between bone fragility fracture (BFF) and abdominal aortic calcification (AAC) has been discussed in recent decade. Objectives: Now we investigated the relationship two a new factor of BFF: serum creatinine-to cystatin C ratio (Cr/CysC). Methods: A total nine-hundred thirty one osteoporotic patients were recruited. Diagnosis osteoporosis was indexed by criteria Japanese Primary Osteoporosis Diagnostic Criteria. Patient’s lumbar spine X-ray pictures taken dual-energy absorptiometry (DXA) hip joint tested at same time, all them followed us for more than year up to nine years with least an administration vitamin D. Anti-osteoporotic drugs administrated 660 patients. Vertebral compression (VF) AAC evaluated lateral view picture. VF classified accordance Semi-quantified method (SQ), as follows: Grade0; No calcification, Grade1; Partial not continued over vertebral height, Grade2; Calcification continuous height. BFF history except harvested from medical record interview. Patients’ background first measurement measured Cr/CysC calculated well. Prevalence baseline each grade SQ compared according AAC. Background factors including mineral densities (BMD) using DXA grade. Occurrence picked during following (BFF_F/U) BFF_F/U ACC statistically compared, evaluated. Results: 219 Grade0, 428 Grade1, 278 Grade2 group 182, 16, 9, 12 138, 98, 122, 70 53, 45, 82, 144 Grade2, Grade-0, Grade-1, Grade-2, Grade-3 SQ, respectively ( p <0.01). Factors that demonstrated significant correlation occurrence sex, age, BMD joint, univariate mode binary logistic regression anaysis. However, did demonstrate multivariate model. 26, 90, 82 The only significantly correlated Grade1 classification. Conclusion: correlates BFF. also after follow under presence Disclosure Interests: None declared.